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Author: kamyk

Phenytoin concurrent use with isoniazid inhibits the metabolism of phenytoin, resulting in increased phenytoin serum concentrations and toxicity; phenytoin dosage adjustments may be necessary during and after isoniazid therapy, especially in slow acetylators of isoniazid ; concurrent use with rifampin may stimulate the hepatic metabolism of phenytoin, increasing its elimination and thus counteracting its anticonvulsant effects; careful monitoring of serum hydantoin concentrations and dosage adjustments may be necessary before and after rifampin therapy .